Friday, August 31, 2012

Shisha smoking as bad as cigarettes for lungs: study

Water-pipe smoking is as bad as deeply inhaling cigarette smoke when it comes to causing respiratory problems, according to a study published on Thursday.

Researchers led by Mohammad Hossein Boskabady at Masshad University of Medical Sciences in Iran monitored lung functions among 57 local water-pipe smokers, 30 deep-inhalation cigarette smokers and 51 normal-inhalation smokers.

They also studied 44 non-smokers for a comparison.

Wheezing occurred among 23 percent of the water-pipe users, 30 percent of the deep-inhalation and 21.6 percent of normal-inhalation cigarette smokers, but only among 9.1 percent of non-smokers.

Coughing occurred among 21 percent, 36.7 percent and 19.6 percent of the smoking groups, compared with 6.8 percent of non-smokers, according to the probe, which measured smokers over three months in two consecutive years.

Sputum production, meanwhile, was found in 14 percent, 10 percent, 3.9 per cent respectively among the various smoking groups, but among 6.8 percent of the non-smoking group.

The results, published in the peer-reviewed journal Respirology, adds a further scientific blow to the defenders of shisha who claim that water pipes are safer because they filter out tobacco toxins.

The water pipe, often used with sweet or fruit-flavoured tobacco, is a centuries-old tradition in the Middle East but in recent years has become fashionable among young westerners, particularly women.

"Our findings reveal that there were profound effects of water-pipe smoking on lung function values, which were similar to the effects observed in deep-inhalation cigarette smokers," Boskabady said in a press release.

"Normal" inhalation cigarette smoking had less of an effect compared to the water pipe, but still contributed significantly to respiratory disorders, the paper stressed.

According to a 2005 study by the UN World Health Organisation (WHO), water pipe smoke has high concentrations of toxic compounds, including carbon monoxide, heavy metals, cancer-causing chemicals and potentially addictive levels of nicotine.

Cigarette smokers typically take eight to 12 puffs over five to seven minutes, inhaling a total of 0.5 to 0.6 of a litre of smoke.

In contrast, waterpipe sessions typically last 20-80 minutes, during which the smoker may take 50-20 puffs which each range from 0.15 to one litre each.

"The waterpipe smoker may therefore inhale as much smoke during one session as a cigarette smoker would inhale consuming 100 or more cigarettes," the WHO said.

The Iranian research used a gadget called a spirometer to measure how deeply smokers inhaled and retained the puff.

"Normal" inhalers typically inhaled less than 10 percent above a benchmark of lung inflation called tidal volume. For "deep" inhalers, it was typically more than 30 percent, and for water-pipe smokers it was usually 40 percent above tidal volume.

Source: http://news.yahoo.com/shisha-smoking-bad-cigarettes-lungs-study-183617996.html

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August 2012 | Furnish and Finish - Property Styling Sydney - Interior ...

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This architecturally designed brand new home placed in the prestigious Bella Vista Waters Estate; houses five bedrooms, multiple living spaces, alfresco entertaining area, landscaped gardens and a designer swimming pool. This property has been finished with state of the art appliances that leave a lasting impression; this large family home offers everything a modern family requires. The property was styled by Jessica Hockley, she decorated this blank canvas with a neutral palette using a lot of beige, brown and black. Vibrancy was added through a variety of blue hues used in cushions throughout the property. The Main living room spoke for its self with the use of a bold orange splash back in the kitchen, creating a fun and casual atmosphere ideal for a family home.

This property is currently being marketed by McGrath Castle Hill, Please contact David Choy for any further enquiries.

Source: http://www.furnishandfinish.com/property-of-the-month/august-2012/?utm_source=rss&utm_medium=rss&utm_campaign=august-2012

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Thursday, August 30, 2012

ArQule plunges on delay in cancer drug study

NEW YORK (AP) ? Shares of ArQule Inc. plunged Wednesday after the company said one of its partners has stopped enrolling patients in a clinical trial of its cancer drug tivantinib.

THE SPARK: ArQule's Japanese partner Kyowa Hakko Kirin Co. temporarily suspended enrollment of patients in a late-stage trial of tivantinib as a treatment for lung cancer. Kyowa made the decision on a recommendation from a safety monitoring committee because some patients are believed to have contracted interstitial lung disease.

Interstitial lung disease is a group of conditions that cause scarring of the lung tissue and impair a patient's ability to breathe. The Mayo Clinic says the scarring is generally irreversible.

ArQule disclosed the stoppage in a form filed with the Securities and Exchange Commission Wednesday. It said Kyowa Hakko Kirin is still treating patients who had already enrolled in the study.

THE BIG PICTURE: Tivantinib is designed to block a molecule that is involved in cancer cell growth, blood vessel formation, survival, and metastasis. It is also being studied as a treatment for liver cancer and other forms of the disease in addition to lung cancer.

Kyowa Hakko Kirin has the rights to market the drug in Japan and some other Asian countries, and Daiichi Sankyo, another Japanese drug company, has the rights to market the drug in the U.S., Europe, South America, and other regions.

In January, ArQule and Daiichi Sankyo said tivantinib delayed the progression of hepatocellular carcinoma, the most common type of primary liver cancer, by 56 percent compared to a placebo.

Tivantinib is ArQule's most advanced drug candidate. The Woburn, Mass., company has three other drugs in early-stage clinical testing.

SHARE ACTION: ArQule shares sank $1.31, or 19.6 percent, to $5.39 in afternoon trading. Earlier the stock dropped 28 percent to $4.81. Before the start of trading on Wednesday, ArQule stock was down 19.5 percent from its annual high of $8.32.

Source: http://news.yahoo.com/arqule-plunges-delay-cancer-drug-study-181642531--finance.html

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Ravens poised to take next step in crowded AFC

Two years, two close calls, and two long offseasons pondering "what if" for the Baltimore Ravens.

What if Billy Cundiff hadn't missed that chip-shot field goal against the Patriots in the AFC championship game eight months ago, the one that would have sent it to overtime? What if Baltimore's usually reliable defense held onto that seemingly comfortable 14-point halftime lead over the hated Pittsburgh Steelers in the divisional round the year before that?

In a league that rarely offers second chances ? let alone third ones ? the Ravens find themselves still searching for that Lombardi Trophy to bookend the one linebacker Ray Lewis led them to a dozen seasons ago.

Time is running out.

Lewis is 37 and noticeably slimmer but he's already logged 222 games at one of football's most demanding positions. Safety Ed Reed turns 34 next month and skipped minicamp while hinting at retirement. Quarterback Joe Flacco is entering his fifth year as a starter and running back Ray Rice is signed to a long-term deal and in his prime.

Anything less than ending the season in New Orleans will be a disappointment.

Coach John Harbaugh has preached "finish" during training camp, the one thing the Ravens haven't done on the cusp of the game's biggest stage. This may be their best ? and perhaps last ? shot at breaking through in a competitive conference in the midst of a transition.

The Steelers begin the season with eyes on a seventh championship, but are also dealing with the kind of roster turnover they've largely avoided during their latest revival.

The Patriots might be the only team in the league nursing a bigger postseason hangover than the Ravens after the New York Giants stunned them ? again ? in the Super Bowl.

Tom Brady's longtime rival Peyton Manning left Indianapolis for Denver, where the Broncos believe the four-time MVP's surgically repaired neck is strong enough to get them back to the Super Bowl for the first time since John Elway was doing his thing.

Houston finally broke the Colts' stranglehold on the AFC South when Manning sat out last season, and the Texans appear to easily be the class of that division as long as quarterback Matt Schaub, running back Arian Foster and wide receiver Andre Johnson stay healthy. The Texans won their first playoff game behind rookie T.J. Yates before falling to Baltimore in the divisional round.

"The key is that you stay focused on your goals and you stay focused on the work," coach Gary Kubiak said, "because you never know how something is going to happen."

___

AFC EAST

Perhaps no player took New England's late collapse against the Giants harder than Brady. Coming off another typically brilliant regular season, Brady was the last Patriots player in uniform in a dejected locker room after a fourth Super Bowl ring vanished. At 35, the window is starting to close on his Hall of Fame career. The offense remains dangerous as long as he's around, though the real issue will be if New England's defense can improve after finishing 31st in yards allowed and crumbling in the final moments against Eli Manning.

The New York Jets were among the NFL's most disappointing teams last fall, sliding to 8-8 as quarterback Mark Sanchez threw a season-killing 18 interceptions and opponents stopped fearing "Revis Island." New York traded for Tim Tebow in the offseason hoping the charismatic if erratic quarterback can make an impact both on the field and in the locker room. Sanchez remains the starter and appears to have kept his sense of humor. He joked the team was saving all its touchdowns for the regular season after the Jets went three straight exhibition games without reaching the end zone. The joke will be on Sanchez and coach Rex Ryan if New York takes another step back.

The Buffalo Bills got off to a hot start a year ago behind quarterback Ryan Fitzpatrick. Then the team signed the QB to a contract extension and immediately started to get buyer's remorse. Buffalo went 2-8 after Fitzpatrick signed the six-year, $59 million deal. He'll need to start earning that paycheck this season, and the Bills have opened their wallets for their defense, signing end Mario Williams to give a toothless defense some bite.

The Miami Dolphins blew things up for the second time in five years, bringing in Joe Philbin as coach and giving the starting quarterback job to rookie Ryan Tannehill. To add a little appeal to a franchise that has ceded the local spotlight to LeBron James and the Miami Heat, the Dolphins signed wide receiver Chad Johnson and let HBO film its popular "Hard Knocks" training camp series with the team. The camera crew lasted longer than Johnson, perhaps a sign the Dolphins realize their problems are not a quick fix.

___

AFC NORTH

Lewis slimmed down during the spring hoping to keep his body fresh. Consider the weight Lewis shed now firmly on Flacco's shoulders. The 27-year-old who once proclaimed himself the best quarterback in football will need to play like it at times for Baltimore to excel. The aging defense will miss the presence of linebacker Terrell Suggs, out indefinitely after tearing his right Achilles tendon while playing pickup basketball.

Pittsburgh remains among the most stable franchises in the NFL, but even they aren't immune to change. In addition to the retirement of wide receiver Hines Ward and the release of linebacker James Farrior ? who have a combined four Super Bowl rings ? Pittsburgh let go offensive coordinator Bruce Arians and brought in former Kansas City coach Todd Haley. Quarterback Ben Roethlisberger likened the transition to Haley's offense to learning a new language. He'll need to get fluent in a hurry behind an injury marred offensive line.

Cincinnati coach Marvin Lewis has made a habit out of turning seemingly untenable situations into playoff berths, doing it a year ago with rookie quarterback Andy Dalton and receiver A.J. Green. Yet consistency has never been the team's trademark. The Bengals have made the postseason in consecutive years only once in franchise history.

The Browns borrowed a page from rival Cincinnati's book by going with 28-year-old rookie quarterback Brandon Weeden and third overall pick Trent Richardson at running back. The Bengals rode that kind of combination to the playoffs. The Browns would love to ride it to somewhere in the vicinity of .500. Yet Richardson spent part of the preseason dealing with a knee issue that could linger into September, and there are plenty of questions about who Weeden will throw to.

___

AFC SOUTH

The Texans could finally exhale after more than a decade of building ? and rebuilding ? landed them in the playoffs. They've got so much depth atop such a lackluster division they could stay there a while. Foster is among the league's best running backs and Schaub was in the midst of a career year before being brought down by injury.

Tennessee nearly tracked down the Texans in the final month of the season despite a lackluster performance from running back Chris Johnson as "CJ2K" became "CJBarely1K." The Titans hope to remain tight on Houston's heels behind second-year quarterback Jake Locker, whose mobility gives Tennessee's offense an added dynamic that could take pressure off Johnson.

The Indianapolis Colts felt so certain about Andrew Luck they hit the reset button on the entire franchise. Manning is gone. So is the coaching staff that took the team to the Super Bowl in 2010. The precocious Luck has looked like a wise investment during the preseason, showing the poise of a player far beyond his 22 years. Having the likes of Reggie Wayne around helps.

Jacksonville owner Shahid Khan is a master marketer who wants to pump some life into the beleaguered Jaguars and is so eager to do it he committed to playing four "home" games in London, one a year starting in 2013. At some point he hopes his team's play on the field ? and not it's travel schedule ? is headline worthy. It just won't be this season.

__

AFC WEST

Norv Turner continues to survive in San Diego despite seemingly diminishing returns. The Chargers woefully underachieved a year ago, as a series of injuries and a midseason slump allowed them to get Tebowed out of the postseason. Philip Rivers tried to largely do it himself, with woeful results. He tossed a career-high 20 interceptions; a healthy TE Antonio Gates should provide a return to normalcy. San Diego addressed its needs on defense by signing linebacker Jarret Johnson and using its first three draft picks on defensive players.

Kansas City made a stunning fall from a 2010 playoff run due to a series of injuries that gutted the roster. Running back Jamaal Charles, quarterback Matt Cassel, safety Eric Berry and tight end Tony Moeaki are all healthy. Having Romeo Crennel ? as placid as former coach Haley was fiery ? should keep the Chiefs on an even keel; so should a user-friendly schedule in the second half of the season.

The sight of Manning wearing orange and blue is going to take some getting used to. Manning felt confident enough in Denver's ability to compete for a title he spurned offers from other teams ? Arizona most notably. Going from Tebow to Manning is one of the most dramatic QB changes in recent memory. The Broncos will need to adapt quickly to be a threat in a tightly packed division.

The Oakland Raiders are so confident in Darren McFadden's health they didn't stop reliable backup Michael Bush from fleeing to Chicago. New coach Dennis Allen is trying to restore a sense of discipline to a franchise that largely ignores the trait. Quarterback Carson Palmer went 4-5 as the starter, but didn't have McFadden in his backfield. Allen's defense could help a defense that struggled in 2011. Still, Palmer will have to throw the ball eventually, and the Raiders haven't had a true No. 1 receiver since Randy Moss.

___

PREDICTED ORDER OF FINISH:

AFC EAST

1) New England

2) New York Jets

3) Miami

4) Buffalo

AFC NORTH

1) Baltimore

2) Pittsburgh

3) Cincinnati

4) Cleveland

AFC SOUTH

1) Houston

2) Tennessee

3) Indianapolis

4) Jacksonville

AFC WEST

1) San Diego

2) Denver

3) Kansas City

4) Oakland

___

Online: http://bigstory.ap.org/NFL-Pro32 and http://twitter.com/AP_NFL

Source: http://news.yahoo.com/ravens-poised-next-step-crowded-afc-214516896--nfl.html

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Bound with Blood

Bound with Blood

(RE-Remake!!)When a Coven of vampires, ruthless and deadly, kill their own kind The Council punishes them in a way that would make most immortals cringe. They are each given a human. A Blood Bond. (Read Inside for More Information! =D)[Old Rpers Welcomed]

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WittyWriter88
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Can I reserve Christina Perri please?

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Can I reserve Adriana (Ashley Benson) please?

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Let us all take a moment to appreciate Toby's cuteness...

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Can I reserve Lucy Hale please?? (:

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Hey again :D this time could i create a hunter ?

"With great party comes great cleaning responsibilities." - Luke Gallagher, SLiDE.

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Tuesday, August 28, 2012

Beware the homeowners association

Homeowners associations can help maintain the value of your home and neighborhood, and provide perks like parks and public pools. But those perks can come at a steep price.

By Trent Hamm,?Guest blogger / August 28, 2012

In this 2006 file photo, a completed home sits in the foreground as homes in another development await completion in San Diego. Homeowners' associations can provide a lot of perks, but at a price. Look at contracts carefully before signing.

Denis Poroy/AP/File

Enlarge

On the surface, homeowners associations can be very good things.

Skip to next paragraph Trent Hamm

The Simple Dollar is a blog for those of us who need both cents and sense: people fighting debt and bad spending habits while building a financially secure future and still affording a latte or two. Our busy lives are crazy enough without having to compare five hundred mutual funds ? we just want simple ways to manage our finances and save a little money.

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For one, they usually ensure a clean-looking neighborhood without anyone letting their property fall into disrepair. In an area with a homeowners association, people don?t have unkempt yards or sidewalks in disrepair.

Associations also provide for the maintenance of common areas. They?ll make beautiful road signs, maintain many of the sidewalks, and sometimes manage a village park.

In some neighborhoods, they enforce quiet hours. In the neighborhood of one of my readers, there was a local number you could call to report quiet hour violations, but they never had to call it because the neighborhood became pretty silent at midnight.

Associations also often provide perks, such as community pools, community parks, club memberships, and the like.

Their goal, in the end, is to preserve and maximize the property value of everyone in the neighborhood.

This can sound wonderful, but it comes with a price.

First, there?s the homeowners association fee. This can vary widely depending on the neighborhood. I?ve heard of fees as low as $30 per month, while others have had monthly fees approaching $1,000. The fees can often be greater than property taxes, believe it or not.

Second, there are often rules that you have to adhere to. This usually includes a list of lawn care and house care responsibilities, but can stretch into other areas as well (such as the aforementioned quiet hours). Some associations require a certain number of volunteer hours per year. Other agreements are very detailed, requiring you to plant certain amounts of certain types of plants in your yard.

Along with that, you have to get association approval for any significant change you want to make. If the change looks too different from the rest of the neighborhood, it won?t be approved, which means that you?ll be unable to do it.

Don?t like these rules? The association can start charging you fines if you ignore them. Ignore the fines, and they can put a lien on your house.

If you?re considering purchasing a new home, you need to find out about any association agreements that the house falls under. You need to make sure that you can afford it and that you?re willing and able to abide by the terms of the agreement.

My take is that there are benefits and drawbacks to associations. They?re great for some and provide a net benefit, but they?re not a great fit for others, particularly those who are really financially pressed.

Make sure you know all of the details before you take the leap into owning a home that participates in a homeowners association.

This post is part of a yearlong series called ?365 Ways to Live Cheap (Revisited),? in which I?m revisiting the entries from my book ?365 Ways to Live Cheap,? which is available at Amazon and at bookstores everywhere.

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Evidence lacking on screening for kidney disease

NEW YORK (Reuters Health) - There isn't enough evidence to recommend checking the kidney function of otherwise healthy people for signs of disease, a government-backed panel said on Monday.

But it's also not clear that using blood or urine tests to screen for chronic kidney disease causes much harm either, according to the U.S. Preventive Services Task Force.

"It's a common condition," said Dr. Joy Melnikow, a Task Force member from the University of California, Davis in Sacramento.

"I was actually struck by how little information there was."

Melnikow told Reuters Health that to recommend kidney screening, the panel would need evidence that testing healthy people - those without diabetes or high blood pressure in particular - would ultimately improve their health.

That would require both a sufficiently accurate test of kidney function as well as a proven treatment for those who test positive for kidney problems.

About one in ten adults has chronic kidney disease, in which the kidneys slowly stop being able to filter and remove waste and extra fluid from the blood.

Kidney disease typically doesn't come with any symptoms until its later stages when damage to the organs is advanced. The vast majority of people with the condition also have high blood pressure or the blood sugar disorder diabetes.

Because of that, recommendations from the American Diabetes Association, for example, call for regular kidney checks in diabetic people. But the current guidelines are only meant to cover healthy, symptom-free people without diabetes or high blood pressure.

Melnikow and the rest of the Task Force said it's unclear how accurate blood and urine tests are at measuring kidney function and how often they come back with false positives - an irregular result for what really is a working kidney.

False positives typically lead to additional testing and can cause healthy people to worry unnecessarily, researchers said.

The USPSTF also couldn't find evidence on whether treating people who are in the early stages of kidney disease but don't have symptoms does them any good in the long run.

If doctors are unsure of what they can do to help those people - and how sick they really are - labeling them with a diagnosis can be problematic, according to Dr. Ann O'Hare, a nephrologist from the University of Washington in Seattle and VA Puget Sound Health Care.

"The concern is that you're going to be telling a large number of people that they have a condition without having anything to offer them and being uncertain about the implications," O'Hare, who wasn't involved in the new guidelines, told Reuters Health.

She said the majority of people with kidney disease are elderly adults with only mildly diminished kidney function.

The new statement was published in the Annals of Internal Medicine, four months after the USPSTF released draft screening guidelines for comment on its website.

MARKETING SCREENING

In another article released in the same journal issue, researchers from the University of Oklahoma School of Community Medicine in Tulsa and the American College of Physicians point to the ethical concerns of marketing other unproven screening tests to the public.

Those direct-to-consumer tests include ultrasounds of the arteries around the heart to check for buildup, or of the heel to screen for osteoporosis.

"Patients can be coerced through unsubstantiated, misleading statements or omission of factual information into obtaining tests where the actual risk may outweigh the proven benefit," Dr. Erik Wallace and his colleagues wrote.

SOURCE: http://bit.ly/MnBiCA Annals of Internal Medicine, online August 27, 2012.

Source: http://news.yahoo.com/evidence-lacking-screening-kidney-disease-210339369.html

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Tropical Storm Isaac slogs toward U.S. Gulf Coast

NEW ORLEANS (Reuters) - Tropical Storm Isaac churned across the Gulf of Mexico on Monday, disrupting U.S. offshore energy production and threatening to hit Louisiana on the anniversary of devastating Hurricane Katrina in 2005.

The storm swiped south Florida on Sunday before moving into warm Gulf waters, where it is expected to strengthen into a hurricane.

On its current track, Isaac was due to slam into the Gulf Coast anywhere between Florida and Louisiana by Tuesday night or early Wednesday, the seventh anniversary of Katrina hitting New Orleans, the U.S. National Hurricane Center (NHC) said.

"The weather is going to go downhill well in advance of that and that's why today is the day of preparation," said NHC director Richard Knabb.

Speaking in an interview with CNN, Knabb said coastal flooding or storm surge up to 12 feet was the biggest threat posed by Isaac, with mandatory evacuations possible across southeastern Louisiana, Mississippi and Alabama.

The governors of all three states have declared states of emergency as a hurricane warning went into effect for the northern Gulf Coast from Louisiana to the Florida Panhandle.

That included New Orleans, devastated when Hurricane Katrina swept over the city on August 29, 2005, killing more than 1,800 people and causing billions of dollars of damage along the coast.

"It is difficult to realize that to the day - seven years after Katrina - another hurricane is headed our way," Mississippi Governor Phil Bryant said.

Late Monday morning, Isaac was about 310 miles southeast of the mouth of the Mississippi River with top sustained winds of 65 mph and moving northwest at 14 mph.

It was expected to be centered over the Gulf Coast no later than early on Wednesday. Evacuation orders for some low-lying parts of the Gulf Coast already were in effect Monday morning.

Energy producers in the Gulf worked to shut down some of their operations ahead of what could be the biggest test for U.S. energy installations since 2008, when Hurricanes Gustav and Ike disrupted offshore oil output for months and damaged onshore natural gas processing plants, pipelines and some refineries.

Gulf residents started stocking up on supplies and securing their homes. In New Orleans, long lines formed at some gas stations and in Gulfport, Mississippi, people crowded supermarkets to buy bottled water and canned food.

"I sense a high level of anxiety," said New Orleans Mayor Mitch Landrieu. "The timing, as fate would have it, on the anniversary of Katrina has everybody in a state of alertness, but that is a good thing."

Isaac is forecast to become a hurricane on Tuesday. In its latest advisory, the NHC said the storm was not expected to strengthen beyond Category 1, the weakest type on the five-step Saffir-Simpson scale of hurricane intensity.

But Knabb said very warm water temperatures in the Gulf, currently ranging between 86 to 87 degrees Fahrenheit (30-30.5 Celsius) could help trigger strengthening beyond Category 1.

"The Gulf of Mexico is almost always plenty warm in August and September to support strengthening tropical storms and hurricanes," he said.

NHC meteorologist Jessica Schauer said the hurricane warning area included "quite a few oil rigs" but not perhaps the heart of the U.S. offshore oil patch, which produces about 23 percent of U.S. oil output and 7 percent of its natural gas.

Despite the threat to offshore oil infrastructure and Louisiana refineries, U.S. crude oil prices were off in late morning trading after being up earlier in Asia. U.S. oil prices were down about $1.15 at $95.

SHUTTING OIL PRODUCTION

Meteorologists at Weather Insight, an arm of Thomson Reuters, predict the storm will spur short-term shutdowns of 85 percent of the U.S. offshore oil production capacity and 68 percent of the natural gas output.

Once ashore, the storm could wreak havoc on low-lying fuel refineries along the Gulf Coast that account for about 40 percent of U.S. refining capacity.

That could send gasoline prices spiking just ahead of the U.S. Labor Day holiday, analysts said. "It's going right in the heart of refinery row," Phil Flynn, an analyst with Price Futures Group in Chicago, said on Sunday.

London-based BP Plc, the biggest U.S. Gulf producer, said it was shutting production at all of its Gulf of Mexico oil and gas platforms and evacuating all workers on Sunday.

Issac's westward track meant the worst of its weather would miss Tampa, Florida, where the Republican National Convention was to open its four-day meeting on Monday. Official convention events were delayed until Tuesday because of the storm.

Tampa, located on Florida's west coast, still faces total rain accumulations of about 15 inches between Sunday and Monday evening, forecasters said.

In south Florida, winds from Isaac forced cancellations of hundreds of flights in and out of Miami, Fort Lauderdale and other south Florida airports on Sunday. Miami-Dade Mayor Carlos Gimenez reported more than 500 cancellations affecting Miami International Airport alone.

The storm killed at least 20 people and caused significant flooding and damage in Haiti and the Dominican Republic before sweeping across the southern tip of Florida on Sunday.

(Additional reporting by David Adams and Kevin Gray in Miami, Emily Le Coz in Tupelo, Matthew Robinson in New York and Kristen Hays in Houston; Writing by Tom Brown; Editing by Bill Trott)

Source: http://news.yahoo.com/isaac-heads-u-gulf-coast-drenching-south-florida-004229748.html

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Monday, August 27, 2012

The ASTRID study

The ASTRID study [ Back to EurekAlert! ] Public release date: 27-Aug-2012
[ | E-mail | Share Share ]

Contact: ESC Press Office
press@escardio.org
European Society of Cardiology

German aortic valve registry aims to determine which valve disease treatment -- TAVI or conventional valve replacement -- is best for which patient

Munich, Germany The German Aortic Valve Registry (GARY) was started in July 2010 and is the only registry so far to include both transcatheter aortic valve implantation (TAVI) and conventional aortic valve replacements and repair.(1) The intention is to deliver a complete picture of current and future practice of treating aortic valve disease and to deliver reliable data on the short and long-term outcome of different treatment strategies. This specifically includes data about quality of life before and after treatment besides numerous medical variables.

Participation in the registry is on a voluntary basis, with 92 German centres (from a possible 99) actively taking part at present. The registry is planned to include patients up to 2015 and to gather a one, three and five-year follow up. It is expected that a total of about 80,000 patients will eventually be enrolled.

By July 2012 more than 26,000 patients were included, of whom 23% were TAVI patients. Current data include 15,252 patients treated in 2011 from 53 centres (when the registry was still in its run-in phase).

First results, presented today at ESC Congress 2012 by Professor Friedrich-Wilhelm Mohr, Clinic Director of the Leipzig Heart Centre, Germany, show that participating centres generally adhered to current guidelines for patient selection; 85% of all TAVI patients were over 75 years and had a higher calculated peri-operative risk of mortality. The mean age of patients who received isolated elective and urgent conventional aortic valve replacement was 68.3 (11.3) years, with a logistic EuroSCORE (log. ES) of 8.8% (9.7%). TAVI patients were on average significantly older (transfemoral 81.0 [6.1] years, transapical 80.3 [6.1] years) and with a higher operative risk.

The reported in-hospital mortality for elective patients was 2.1% for conventional surgery, 5.1% for the transfemoral TAVI and 7.7% for the transapical approach. These numbers confirm the good results of recent studies and reflect the growing experience in treatment and perioperative management of aortic valve disease. The high procedural success of more than 97% and the low rate of valve-related reinterventions (less than 0.5%) are also indicative of the latest improvements.

Stratification of the patients into risk groups revealed a particular benefit for people with high (log. ES >20%) and very high (log. ES >30%) risk when treated transfemorally, with mortality rates of 4.7% and 7.7%, respectively.

Consistent with earlier observations, the overall number of cerebrovascular events during hospital stay was low in the conventionally treated group (2.2%) and somewhat higher for TAVI patients (transfemoral 3.7%, transapical 3.5%). The rate of vascular complications was reported as 11.9% for the transfemoral, 2.5% for the transapical and 1.0% for the conventional group. However, the number of patients who needed more than two units of packed red blood cells was 29.4% in conventional surgery and 25.4% with the transapical, but only 11.5% with the transfemoral approach.

The number of postoperatively new pacemaker implants was 23.7% in the transfemoral group - significantly higher than in the transapical (9.9%) and in the conventional surgical groups (4.6%). Here, significant differences between the two predominantly transfemorally implanted valve types were noted (29.4% Corevalve, 12.1% Edwards Sapien). The amount of residual aortic regurgitation was also reported to be different with the Corevalve (grade 0 29.6%, grade I or II 70.0%, more than grade II 0.4%) and the Edwards Sapien prosthesis (grade 0 53.8%, grade I or II 45.7%, more than grade II 0.4%).

Commenting on the results, Professor Mohr said: "From these first data it can be concluded that the patients in the participating German centres were treated according to the guidelines, which led to low in-hospital mortality in all groups as compared to former surveys. Patients in high risk groups benefit at least as much from TAVI procedures as from conventional surgery, particularly when performed transfemorally.

"Post-procedural rates of cerebrovascular events, vascular complications, renal failure and blood transfusions have decreased but need further attention. The high number of patients in the register will allow for thorough risk factor analysis for these complications. Additional long-term follow-up is to evaluate the high number of pacemaker implants as well as residual aortic regurgitation in the TAVI group. The German aortic valve registry was especially designed to make an important contribution to the ongoing discussion on these subjects. With the help of subgroup analyses and stratification for risk factors, we also expect to detect which treatment is best for which patient."

GARY was inaugurated by the German Society of Cardiology and the German Society for Thoracic and Cardiovascular Surgery because of the remarkable growing numbers of TAVI over the past few years. It is supported by the German Heart Foundation and receives unrestricted grants from the heart valve manufacturing industry.

###

Notes to editors

Please note that the author's photo and CV as well as the spokesperson's CV can be found here

Introduced as recently as 2002, TAVI has been taken up with unprecedented enthusiasm. Offering for the first time a catheter-based treatment for non-surgical and high-risk patients with valve disease (such as aortic stenosis), TAVI has been rapidly adopted in Europe, and especially in Germany, despite the absence of data from large patient populations or randomized trials.

About the European Society of Cardiology www.escardio.org

The European Society of Cardiology (ESC) represents more than 75,000 cardiology professionals across Europe and the Mediterranean. Its mission is to reduce the burden of cardiovascular disease in Europe.

About ESC Congress 2012

The ESC Congress is currently the world's premier conference on the science, management and prevention of cardiovascular disease. ESC Congress 2012 takes place 25-29 August at the Messe Mnchen in Munich. The scientific programme is available at: http://spo.escardio.org/Welcome.aspx?eevtid=54

More information is available from the ESC Press Office at press@escardio.org.


[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


The ASTRID study [ Back to EurekAlert! ] Public release date: 27-Aug-2012
[ | E-mail | Share Share ]

Contact: ESC Press Office
press@escardio.org
European Society of Cardiology

German aortic valve registry aims to determine which valve disease treatment -- TAVI or conventional valve replacement -- is best for which patient

Munich, Germany The German Aortic Valve Registry (GARY) was started in July 2010 and is the only registry so far to include both transcatheter aortic valve implantation (TAVI) and conventional aortic valve replacements and repair.(1) The intention is to deliver a complete picture of current and future practice of treating aortic valve disease and to deliver reliable data on the short and long-term outcome of different treatment strategies. This specifically includes data about quality of life before and after treatment besides numerous medical variables.

Participation in the registry is on a voluntary basis, with 92 German centres (from a possible 99) actively taking part at present. The registry is planned to include patients up to 2015 and to gather a one, three and five-year follow up. It is expected that a total of about 80,000 patients will eventually be enrolled.

By July 2012 more than 26,000 patients were included, of whom 23% were TAVI patients. Current data include 15,252 patients treated in 2011 from 53 centres (when the registry was still in its run-in phase).

First results, presented today at ESC Congress 2012 by Professor Friedrich-Wilhelm Mohr, Clinic Director of the Leipzig Heart Centre, Germany, show that participating centres generally adhered to current guidelines for patient selection; 85% of all TAVI patients were over 75 years and had a higher calculated peri-operative risk of mortality. The mean age of patients who received isolated elective and urgent conventional aortic valve replacement was 68.3 (11.3) years, with a logistic EuroSCORE (log. ES) of 8.8% (9.7%). TAVI patients were on average significantly older (transfemoral 81.0 [6.1] years, transapical 80.3 [6.1] years) and with a higher operative risk.

The reported in-hospital mortality for elective patients was 2.1% for conventional surgery, 5.1% for the transfemoral TAVI and 7.7% for the transapical approach. These numbers confirm the good results of recent studies and reflect the growing experience in treatment and perioperative management of aortic valve disease. The high procedural success of more than 97% and the low rate of valve-related reinterventions (less than 0.5%) are also indicative of the latest improvements.

Stratification of the patients into risk groups revealed a particular benefit for people with high (log. ES >20%) and very high (log. ES >30%) risk when treated transfemorally, with mortality rates of 4.7% and 7.7%, respectively.

Consistent with earlier observations, the overall number of cerebrovascular events during hospital stay was low in the conventionally treated group (2.2%) and somewhat higher for TAVI patients (transfemoral 3.7%, transapical 3.5%). The rate of vascular complications was reported as 11.9% for the transfemoral, 2.5% for the transapical and 1.0% for the conventional group. However, the number of patients who needed more than two units of packed red blood cells was 29.4% in conventional surgery and 25.4% with the transapical, but only 11.5% with the transfemoral approach.

The number of postoperatively new pacemaker implants was 23.7% in the transfemoral group - significantly higher than in the transapical (9.9%) and in the conventional surgical groups (4.6%). Here, significant differences between the two predominantly transfemorally implanted valve types were noted (29.4% Corevalve, 12.1% Edwards Sapien). The amount of residual aortic regurgitation was also reported to be different with the Corevalve (grade 0 29.6%, grade I or II 70.0%, more than grade II 0.4%) and the Edwards Sapien prosthesis (grade 0 53.8%, grade I or II 45.7%, more than grade II 0.4%).

Commenting on the results, Professor Mohr said: "From these first data it can be concluded that the patients in the participating German centres were treated according to the guidelines, which led to low in-hospital mortality in all groups as compared to former surveys. Patients in high risk groups benefit at least as much from TAVI procedures as from conventional surgery, particularly when performed transfemorally.

"Post-procedural rates of cerebrovascular events, vascular complications, renal failure and blood transfusions have decreased but need further attention. The high number of patients in the register will allow for thorough risk factor analysis for these complications. Additional long-term follow-up is to evaluate the high number of pacemaker implants as well as residual aortic regurgitation in the TAVI group. The German aortic valve registry was especially designed to make an important contribution to the ongoing discussion on these subjects. With the help of subgroup analyses and stratification for risk factors, we also expect to detect which treatment is best for which patient."

GARY was inaugurated by the German Society of Cardiology and the German Society for Thoracic and Cardiovascular Surgery because of the remarkable growing numbers of TAVI over the past few years. It is supported by the German Heart Foundation and receives unrestricted grants from the heart valve manufacturing industry.

###

Notes to editors

Please note that the author's photo and CV as well as the spokesperson's CV can be found here

Introduced as recently as 2002, TAVI has been taken up with unprecedented enthusiasm. Offering for the first time a catheter-based treatment for non-surgical and high-risk patients with valve disease (such as aortic stenosis), TAVI has been rapidly adopted in Europe, and especially in Germany, despite the absence of data from large patient populations or randomized trials.

About the European Society of Cardiology www.escardio.org

The European Society of Cardiology (ESC) represents more than 75,000 cardiology professionals across Europe and the Mediterranean. Its mission is to reduce the burden of cardiovascular disease in Europe.

About ESC Congress 2012

The ESC Congress is currently the world's premier conference on the science, management and prevention of cardiovascular disease. ESC Congress 2012 takes place 25-29 August at the Messe Mnchen in Munich. The scientific programme is available at: http://spo.escardio.org/Welcome.aspx?eevtid=54

More information is available from the ESC Press Office at press@escardio.org.


[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Source: http://www.eurekalert.org/pub_releases/2012-08/esoc-tas082712.php

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Oil companies pull back as Isaac roars toward Gulf

Oil companies scrambled out of the path of Tropical Storm Isaac, withdrawing offshore workers and cutting oil and gas production in the Gulf of Mexico.

By mid-day Sunday, the U.S. government said that daily oil production in the Gulf was down 24 percent and natural gas production was off 8 percent.

Isaac, already carrying winds of more than 60 miles an hour, was expected to cross the Florida Keys by late afternoon. The storm will likely pick up strength from the warm, open waters of the Gulf of Mexico and strike as a dangerous Category 2 hurricane somewhere between New Orleans and the Florida Panhandle on Wednesday, the seventh anniversary of Hurricane Katrina.

Noting that the storm was moving west and threatening to grow more powerful, energy giant BP evacuated all its installations and temporarily halted production in the Gulf Sunday. Earlier, it had pulled workers from its massive Thunder Horse platform in the eastern Gulf.

Royal Dutch Shell is withdrawing all workers and suspending production in the eastern Gulf. It is pulling out all but essential personnel and cutting production in the central Gulf.

Apache Corp., a Houston oil services company, is withdrawing 750 workers and contractors from its installations in the eastern Gulf. It is also cutting production of oil and natural gas. Other energy companies have also been evacuating their platforms and rigs in the Gulf.

Murphy Oil Corp., based in El Dorado, Ark., said Sunday that it is pulling out all workers and suspending operations in the Gulf.

Overall, oil companies pulled workers off 39 (7 percent) of 596 production platforms and eight (11 percent) of 76 Gulf oil rigs, the U.S. Bureau of Safety and Environmental Enforcement reported Sunday.

Former energy trader Stephen Schork, who now edits a report on the oil industry, worries that the storm will be a repeat of Hurricanes Katrina in 2005 and Gustav in 208, damaging Gulf refineries and pipelines and disrupting oil tanker traffic.

But Fadel Gheit, oil analyst at Oppenheimer & Co., says that the explosion that rocked an oil refinery in Venezuela on Saturday, killing 26 people, will likely have a bigger impact than Isaac. It could drive up gasoline prices and "further erode consumer confidence and derail (the) economic recovery."

Associated Press

Source: http://hosted2.ap.org/APDEFAULT/f70471f764144b2fab526d39972d37b3/Article_2012-08-26-Isaac-Rigs/id-453b6eb4ce58462a9a18ba8f172376d4

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Oil rises more than $1, tropical storm threatens supply

SINGAPORE (Reuters) - Oil futures rose more than a dollar on Monday, with Brent climbing above $115 per barrel, on supply worries as Tropical Storm Isaac threatened to interrupt most U.S. offshore oil production in the Gulf of Mexico.

Oil prices got a further shot in the arm from hopes of more U.S. stimulus measures, which would boost the outlook for demand from the world's top consumer of oil.

Brent crude futures rose $1.31 to $114.90 a barrel by 0437 GMT, after rising to a high of $115.50 earlier in the session. U.S. crude was up $1.06 to $97.21.

"The storm will have a temporary impact on prices. But everyone is waiting for the European Central Bank and U.S. Federal Reserve meetings ahead," said Tony Nunan, a risk manager at Mitsubishi Corp in Tokyo.

"Technically, Brent has been strong, so it looks like it's continuing that trend after the temporary blip on Friday and simply reversing the falls."

Oil prices fell on Friday after a report that the International Energy Agency is likely to tap strategic oil reserves as soon as September, dropping its resistance to a U.S.-led plan.

But prices are now turning upwards ahead of the annual U.S. Jackson Hole meeting of central bankers and economists later this week, where Fed Chairman Ben Bernanke will deliver a speech that will be scoured for clues on a third round of quantitative easing.

The markets will also look for policy signals from the euro zone ahead of a September 6 meeting of the European Central Bank.

"The markets are now getting excited on the possibility of additional monetary stimulus by the Federal Reserve," said Ben Le Brun, a Sydney-based market analyst at OptionsXpress.

"I don't think traders will want to be caught short ahead of the Jackson Hole meeting especially when there's an upside risk."

SUPPLY DISRUPTION FEARS

Oil prices drew support from the threat to U.S. offshore oil production in the Gulf of Mexico from the Tropical Storm Isaac -- which is expected to strengthen to a Category 2 hurricane and hit the Gulf Coast somewhere between Florida and Louisiana at midweek. .

Meteorologists at Weather Insight, an arm of Thomson Reuters, predict the storm will spur short-term shutdowns of 85 percent of the U.S. offshore oil production capacity and 68 percent of the natural gas output.

The Gulf of Mexico accounts for about 23 percent of U.S. oil production and 7 percent of natural gas output, according to the U.S. Energy Information Administration.

About 30 percent of U.S. natural gas processing plant capacity and 44 percent of the country's refining capacity also line the Gulf Coast, the EIA said.

There are other supply worries as well.

Delays in Iraq's pipeline construction threaten to stall production at Royal Dutch Shell's Majnoon oilfield for at least three months, forcing the field to miss a 2012 target of 175,000 barrels per day.

In Norway, oil services workers broke off wage talks with oil companies on Friday, taking the sector a step closer to its second strike within two months.

Norway's vital oil sector was hamstrung last month when production workers held a 16-day strike over pay and the right to early retirement, driving up oil prices.

An upcoming maintenance-related drop in North Sea output and ongoing Middle East turmoil also underpinned Brent prices.

Britain's largest oilfield, Buzzard, which is the single biggest contributor to the Forties crude oil stream and usually sets the price of the Brent benchmark, will shut next month, suspending output until mid-October.

Adding to Middle East uncertainties, Iran's foreign minister urged delegates at a Non-Aligned Movement developing nations summit on Sunday to oppose sanctions imposed by the West on the Islamic Republic to punish it for its nuclear activities.

Source: http://news.yahoo.com/oil-rises-more-1-tropical-storm-threatens-supply-060516264--finance.html

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Sunday, August 26, 2012

Tropical Storm Isaac starts lashing Florida Keys

KEY WEST, Fla. (AP) ? Tropical Storm Isaac gained fresh muscle Sunday as it bore down on the Florida Keys, with forecasters warning it could grow into a dangerous Category 2 hurricane as it nears the northern Gulf Coast.

Isaac drew new strength early Sunday during a warm-water crossing of the Florida Straits after causing weekend havoc in Cuba, where it downed trees and power lines. Before that, Isaac was blamed for four deaths in Haiti.

On Key West, locals followed time-worn storm preparedness rituals while awaiting the storm after Isaac swamped the Caribbean and shuffled plans for the Republican National Convention. The U.S. National Hurricane Center said Sunday that Isaac had started lashing the Keys with rain and wind by late morning.

A steady line of cars moved north Saturday along the Overseas Highway, the only road linking the Florida Keys. Residents boarded up windows, laid down sandbags and shuttered businesses ahead of the approaching storm. Even Duval Street, Key West's storied main drag, was subdued for a weekend, though not enough to stop music from playing or drinks from being poured.

"We'll just catch every place that's open," said Ted Lamarche, a 48-year-old pizzeria owner visiting Key West to celebrate his anniversary with his wife, Deanna. They walked along on Duval Street, where a smattering of people still wandered even as many storefronts were boarded up and tourists sported ponchos and yellow slickers.

"Category None!" one man shouted in a show of optimism.

The Keys were bracing storm surge of up to four feet, strong winds and the possibility of tornadoes. The island chain's two airports closed Saturday night, and volunteers and some residents began filing into shelters.

"This is a huge inconvenience," said Dale Shelton, a 57-year-old retiree in Key West who was staying in a shelter.

Isaac has already left a trail of suffering across the Caribbean.

The storm's center made landfall Saturday near the far-eastern tip of Cuba, downing trees and power lines. In the picturesque city of Baracoa, the storm surge flooded the seaside Malecon and a block inland, destroying two homes.

At least four people were reported dead in Haiti, including a 10-year-old girl who had a wall fall on her, according to the country's Civil Protection Office. The government also reported "considerable damage" to agriculture and homes. Nearly 8,000 people were evacuated from their houses or quake shelters and more than 4,000 were taken to temporary shelters.

The Grise River in Haiti overflowed north of Port-au-Prince, sending chocolate-brown water spilling through the sprawling shantytown of Cite Soleil, where many people grabbed what possessions they could and carried them on their heads, wading through waist-deep water.

Scores of tents in quake settlements collapsed. In a roadside lot in Cite Soleil, the dozens of tents and shelters provided by international groups after the earthquake were tossed to the ground like pieces of crumpled paper, and the occupants tried to save their belongings.

After Isaac passes the Keys, it will move over the warm, open waters of the Gulf of Mexico and is expected to gain significant strength. It could ultimately make landfall on the northern Gulf Coast late Tuesday or early Wednesday. However, forecasters have stressed that the storm's exact path remains highly uncertain.

"Definitely the northern Gulf Coast should be preparing for a hurricane right now," Jessica Schauer, a meteorologist with the U.S. National Hurricane Center in Miami, told The Associated Press in a phone interview.

A Category 2 hurricane is capable of top sustained winds of 96 to 110 mph (154 to 177 kph).

Isaac isn't likely to hit Tampa head-on, but it could still lash the city with rain and strong winds just as the convention ramps up. A tropical storm warning is in effect for parts of Florida's west coast, including Tampa Bay.

Convention officials said they would convene briefly on Monday, then immediately recess until Tuesday afternoon, when the storm is expected to have passed. Florida Gov. Rick Scott, a Republican, declared a state of emergency and canceled his plans to attend convention events on Sunday and Monday.

As of 8 a.m. EDT, the storm was centered about 80 miles (129 kilometers) southeast of Key West, according to the U.S. National Hurricane Center in Miami. Isaac had top sustained winds of 65 mph (100 kph).

It was moving to the west-northwest toward the Keys at 18 mph (29 kph). Tropical storm-force winds extended outward up to 205 miles (335 km) from the center, meaning storm conditions were possible in many places even if Isaac does not pass directly overhead.

A hurricane warning was in effect for the Keys, including the Dry Tortugas and for the west coast of Florida from Bonita Beach south to Ocean Reef, among some other areas, authorities said.

Meanwhile, a hurricane watch was in effect from east of Morgan City, La. ? including the New Orleans metro area ? eastward to Indian Pass., Fla.

___

Associated Press writers Bill Barrow in Tampa, Fla.; Trenton Daniel and Evens Sanon in Port-au-Prince, Haiti; Peter Orsi and Anne-Marie Garcia in Havana; Fernando Gonzalez in Baracoa, Cuba; and Ezequiel Abiu Lopez in Santo Domingo, Dominican Republic, contributed to this report.

Source: http://news.yahoo.com/tropical-storm-isaac-starts-lashing-florida-keys-151909249.html

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zeitgeistblog: Google News: Korean Court Helps Samsung - Wall Street Journal http://t.co/v1wWUUUe

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Source: http://twitter.com/zeitgeistblog/statuses/239201125830623234

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